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This site is lovingly-crafted using CSS3 and a smattering of XHTML. I did start off with that thar new-fangled HTML5 malarkey, but my web server kept interfering. Whilst HTML5 isn’t yet a standard, all decent browsers support it (Safari, Chrome, Firefox et al). If you want to know more about HTML5, then I recommend (most effusively), Dive into HTML5 originally from Mark Pilgrim, now maintained by others.
My proof-of-concept HTML5 stuff was translated into plain old HTML / CSS for those browsers less capable, using the splendid HTML5 “shiv” from Remy Sharp.
I try to be mobile-friendly courtesy of some CSS3 media queries trickery, which re-arranges the bits for your more cramped viewing pleasure.
So the front-end is hand-crafted mark-up, CSS and Javascript. What about the back-end? Well, it’s on an ancient NoSQL solution called IBM Domino. Woof.
Hosting-wise, we do it ourselves in the London Developer Co-op, using Amazon’s very lovely web services.